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Southall Lab
*Recent papers/preprints!*
Neuronal protein Sex-lethal modulates tRNA synthesis via the polymerase III subunit Polr3E in male Drosophila neurons PLOS Biology
NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation
EMBO Reports
AGES: An auxin-inducible, GAL4-compatible, gene expression system for Drosophila eLife
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Gene regulatory mechanisms underlying neuronal differentiation
We are interested in how transcription factors and genome remodelling drive differentiation of neurons. Using the wonderful Drosophila model and cell specific profiling methods, we are investigating the mechanisms that drive the maturation of newly born neurons, causing them to lose cell fate plasticity and acquire specific properties,.
Targeted DamID (TaDa)
Targeted DamID (TaDa) is a method for profiling protein-DNA interactions in a cell type-specific manner (Southall et al., 2013).
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